Which hormone increases osteoclast activity?

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Enhance your NBEO Histology Test preparation skills with our quiz. Dive into multiple choice questions explained with hints and detailed answers. Ace your NBEO exam with confidence!

Multiple Choice

Which hormone increases osteoclast activity?

Explanation:
Rising parathyroid hormone signals bone to release calcium by boosting osteoclast activity. It acts on osteoblast lineage cells to shift the RANKL/OPG balance toward more RANKL and less OPG, which promotes differentiation and activation of osteoclasts. The result is increased bone resorption and calcium release into the bloodstream, helping restore calcium levels after a drop. Calcitonin directly inhibits osteoclasts, reducing resorption; estrogen lowers osteoclast lifespan and activity; growth hormone mainly promotes bone formation and remodeling with anabolic effects rather than increasing osteoclast activity. So the hormone that increases osteoclast activity is the parathyroid hormone.

Rising parathyroid hormone signals bone to release calcium by boosting osteoclast activity. It acts on osteoblast lineage cells to shift the RANKL/OPG balance toward more RANKL and less OPG, which promotes differentiation and activation of osteoclasts. The result is increased bone resorption and calcium release into the bloodstream, helping restore calcium levels after a drop. Calcitonin directly inhibits osteoclasts, reducing resorption; estrogen lowers osteoclast lifespan and activity; growth hormone mainly promotes bone formation and remodeling with anabolic effects rather than increasing osteoclast activity. So the hormone that increases osteoclast activity is the parathyroid hormone.

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